Applications Of Lanthanides For Medicine

Applications Of Lanthanides For Medicine Lanthanides have been used for medicinal applications since the 1980s but the development of technology has led to a demand for new developments.1 Lanthanides, known as rare-earth elements, have a wide range of photophysical properties that are amenable to spectroscopic and crystallographic studies.1 This, along with the absence of lanthanides in biological systems, makes them ideal for studying protein structure and interactions. The chemistry of lanthanides arises from the shielded electrons in the 4f orbitals, located within the outermost filled 5s/5p orbitals2. This shielding means the luminescent f-f transitionsehibited by lanthanides are almost ligand-dependent. Despite their chemical similarities each lanthanide gives its own distinctive colour, luminescence emission spectra and nuclear magnetic properties.2 They are electropositive, very reactive and favour the Ln3+ oxidation state. It is these properties that make them useful as medicinal agents.1 Figure The f block lanthanidesLn3+ ions have similar ionic radii, donor atom preferences and coordination numbers in binding sites as Ca2+ ions which means that to some extent Ln3+ can mimic Ca2+ behaviour.3 For drugs molecules to reach their target they first need to be absorbed across the cell membrane a calcium dependent process. Calcium concentrations of mM are needed for efficient drug uptake, but these are rarely achieved under cellular conditions and even when it is the cell is likely to become damaged.3 It has recently been found that Ln3+ can perforate the membrane at concentrations as low as 10-5 M. It is therefore no surprise that co-administration of drugs with Ln3+ has led to an increased intracellular accumulation.3 This property has allowed lanthanides to be used as a co-administer to drugs, as a drug itself and imaging agents.3 Medicinal applications Anti cancer agents Lanthanides have been known to be anti cancer agents since the early 1990s primarily through the induction of apoptosis.3 Lanthanides, particularly Tb3+, increase the infux of Ca2+ into cells thus increasing the intracellular levels. This increases the endonuclease activity, leading to DNA cleavage and therefore apoptosis.4 The same result is achieved by the inhibition of phosphodiesterase, the molecule responsible for the degradation of cyclic adenosine 3,5-monophosphate (cAMP).4,5 The molecule cAMP has an important role in DNA replication and an increase in its levels leads to a corresponding increase in the protein kinase (PKA) levels. This has two effects both of which lead to apoptosis; the increase of endonuclease activity and the expression of apoptosis genes.3,5 However, these methods were not selective and influenced healthy tissues as well as cancerous ones.4 New developments have targeted this drawback in an attempt to limit the side effects of treatment. Titania nanoparticles (NPs) have the potential to target tumours in a non-invasive manner.4 Titania, a wide band gap semiconductor, produces reactive oxygen species (ROS) following excitation of valence band electrons to the conductance band upon stimulation.4 These photoelectrochemical reactions can be promoted by x-ray irradiation which allows non-invasive penetration of the human body. Two papers, published by H.Townley et al. and A.Gnach et al., reported the discovery that the interaction of titania-NPs with x-rays can be optimised by using lanthanides as dopants.4,5 Normal cells can tolerate a certain level of exogenous ROS due to a reserve of antioxidants which counteract the ROS activity.3 Cancerous cells have metabolic abnormalities which increase the intracellular ROS levels. This makes them more dependent on the intracellular antioxidant system and vulnerable to exogenous ROS levels.4,5 Lanthanide doped NPs generate higher levels of ROS, due to the lanthanides allowing increased x-ray absorption, than general NPs thus playing on this vulnerability. The increased levels cause DNA and mitochondrial damage, causing apoptosis.4,5 NPs have the capability to accumulate in tumours as a result of the defective tumour vasculature. This gives them the potential to be selective to cancer cells thus reducing side effects. The NPs can also be coated with moieties for specific targeting and activation further limiting the damage to healthy tissues.5 These properties of the NPs are enhanced by lanthanide doping thus giving a new application for lanthanides. The best results have been seen for [emailprotected] and [emailprotected] Imaging Figure The traditional contrasting agent with Gd3+ bound to the chelate ligand and the water molecule under observation.Magnetic Resonance Imaging (MRI) has been vastly improved due to the use of contrasting agents (CA) since 1988.6 These act to improve the contrast between healthy and pathological tissue by influencing the relaxation rate of protons of bound water molecules, T2.7 The faster the relaxation rate, the higher the intensity and the sharper the image achieved. Relaxation rates are increased when the water molecule is close to a paramagnetic centre. Gd3+ has 7 unpaired electrons and is used as contrasting agents in MRI due to its highly paramagnetic centre.6 The traditional contrasting agents used Gd3+ bound to a chelate ligand through eight donor atoms (figure 2). This gives the complex the stability and strong binding needed to ensure that Gd3 is not released into the blood.6 However, Gd3+ is unselective and distributes over a wide region of extracellular space. Develop ments have been made to make the distribution more selective by linking Gd3+ chelates to moieties that cause accumulation in areas of interest.7 However, the increase of the magnetic strength from 64 MHz to the present 125 MHz has led to the decrease in the efficiency of Gd3+ based CAs. Therefore developments have had to be made to meet the technological demands. Current commercial contrasting agents are based on Gd-DPTA, Gd-DOTA and their derivatives but utilizing the magnetic and luminescent properties of other lanthanides has allowed the developments of new CA.8 A paper recently published by C.Andolinia et al. described how the near infrared (NIR) luminescence of the lanthanides Dy3+Â  and Yb3+ has been combined with the traditional MRI-CA to create new multimodal imaging agents.6 These complexes act as light harvesting antenna due to the bifunctional chelators/chromophores present. They surround the reaction centre, in this case the tissues, and funnel absorbed energy to the reaction centre.8 It is through this method that more of the incoming radiation is absorbed and the contrast is improved. Optical probes absorb photons from the excitation source within the visible region as well as absorbing the photons caused by biomolecules.6 Therefore the absorption and luminescent emission of optical probes are both in the visible region which l eads to a decrease in the limit of detection as well as the depths that the photons can reach. The NIR probes have the advantage that the depth of light penetration is increased due to their excitation wavelengths being outside of the biological window.6 Evaluation of all of the lanthanides has shown Yb3+ to be the most efficient NIR and MRI bimodal imaging agent.7 Osteoporotic treatment Bones are involved in a very precise cycle of the resorption and desorption of the bone tissue, see figure 3. Osteoporosis is a skeletal disease in which the bone density is decreased through higher levels of resorption than desorption. It is most commonly treated with biphosphonates which inhibit resorption thus preventing bone degradation.9 However, this class of drugs is poorly lipophilic and thus have a low oral bioavailability. To counteract this, the drug must be administered in high concentrations which causes GI tract problems, low patient tolerability and suspected osteoporotic issues in the jaw.9 Figure The continuous cycle of bone degradation and rebuildingIt is well known that lanthanide ions preferentially accumulate within the bone3 where they have an inhibitory effect on osteroclasts (bone degradation) and a stimulatory effect on osteoblasts (bone making). Due to the chemical similarities of Ln3+ and Ca2+ mentioned before, Ln3+ can potentially replace Ca2+ ions within the bone and affect the bone turnover cycle.3 Y.Mawani et al. discovered that heavier lanthanide ions show a 50-70% accumulation in the bones compared to lighter ions which have a >25% accumulation.9 The half life for a lanthanide ion in the bone is 2.5 years compared to an elimination time from soft tissues, such as the liver, of 15 days. These properties have led to heavier lanthanide ions being used for osteoporotic therapy.9 Furthermore, adjustment of the ligand structure has allowed the improvement of oral availability leading to an increased uptake and reduced side effects. Previous lanthanide comple xes were found to be poorly soluble in aqueous phases therefore reducing the absorption across the GI tract.9 This led to small levels of lanthanide ions accumulating in the bones therefore making the treatment inefficient. The development of an orally active drug that can pass through the GI tract has allowed efficient delivery of lanthanides to the bone. Conclusion Despite the initial disregarding of lanthanides due to suspected toxicity they have shown to have excellent properties for use as medicinal agents. The similarity of Ln3+Â  and Ca2+ has allowed lanthanides ions to be used as anti-osteoporotic agents as well as for increasing the permeability of cells to other drugs. New developments have seen lanthanide ions being used as cancer agents, by causing increased levels of ROS, as well as improving the already existing imaging techniques.

Advertising-Critical Appraisal Essay

Abstract: The paper traces the journey of television in India which started for promoting development and serving the cause of the poor and the underprivileged. While some efforts were made to fulfil these brave goals, television also earned the unholy reputation of being a vehicle for government propaganda. Doordarshan – the public service broadcaster was the only available terrestrial network till 1991 when transnational satellite television channels began to make forays into the country. Soon Indian players entered the television industry thereby leading to enormous expansion. Since then, the very nature of Indian broadcasting has changed. Television has transformed from a medium devoted to development communication and the cause of the marginalised, to a true middle-class medium. Contemporary Indian television is divorced from the realities of the ‘other half of India that lives in abject poverty and deprivation, thus presenting a distorted view of social reality. This paper seeks to examine these and other related issues, and make some suggestions for policy initiatives to put the development agenda back on television. See more: The Issues Concerning Identity Theft Essay Keywords: Indian television, Doordarshan, television and development communication, public service broadcasting, commercialisation of Indian television, broadcast regulation 1 Introduction Out of the different mass media such as newspapers, radio, television, internet among others, the one introduced in the country with the aim of promoting development was television. Television began in India in 1959 as an educational project supported by the United Nations Educational Scientific and Cultural Organisation (UNESCO) and the Ford Foundation. Television was based on the model of a public broadcasting system prevalent in many countries of Europe. In independent India, the political leaders recognised the value of information and its use for accelerating the process of development. Thus was started a model of public broadcasting committed to inform, educate and entertain the people. The then Prime Minister of India, Jawaharlal Nehru decided to have full government control over broadcasting for the time being. In retrospect, many observers feel that it was the hangover of the colonial legacy of controlling the media and fears about the power of the mass media to inflame social conflicts that prevented Indian policy makers from thinking creatively about radio and television in the country (Agrawal and Raghaviah, 2006; Jeffrey, 2006). In the decades since 1959, vast changes took place in the television landscape of India. In its early years, apart from being used as an educational tool, television was also misused as a mouthpiece for the central government and the party in power. Programming was primarily in Hindi and much of the news and current affairs focussed on Delhi – the seat of political power (Johnson, 2000; Singhal and Rogers, 2001). Thus, while television was entrusted with the brave goal of promoting national integration, the same medium was found to reinforce a sense of alienation in many parts of the country particularly in the north-eastern states (Joshi, 1985; Ninan, 1995; Page and Crawley, 2001). Despite being the world leader in experimenting with television and satellite technology, India failed to capitalise on the lessons learnt from early development communication projects such as the Satellite Instructional Television Experiment (SITE) and the much acclaimed Kheda Communication Project (Singhal and Rogers, 2001). Contemporary Indian television is criticised by many for having shifted from its humanitarian goals and becoming a medium for the urban middle class. It is this class which owns and operate most of the television industry in India. It is the same class which is transmitting its own values, principles, and opinions to the rest of India (Johnson, 2000). Consequently, the cause of the poor, underprivileged people for whose development the medium was brought to the country has suffered a setback. Changes in the television system did not occur in India alone. There was a worldwide trend during the 1980s towards the commercialisation of television. Herman and Mc Chesney (2001) argue that during this decade the policies of deregulation and privatisation were applied to national broadcasting and telecommunication systems that were traditionally regulated and often publicly owned and operated. This had a detrimental impact on public service programs which were replaced with more and more entertainment programming. The subsequent sections in the paper examine the divergence between the rhetoric of television for development and actual practice. Some of the ground-breaking initiatives in development communication using television are also captured. Before that, it becomes essential to dwell on the concept of development communication and the role of media is social change. Role of Media in Development It is important at this point to clarify the meaning of „development communication‟ for the term has a wide variety of connotations. Development communication is more than agricultural extension or rural communication. It doesn‟t restrict itself merely to the development of rural areas, nor is it concerned with agricultural development alone. It is oriented towards development whether it be in rural or urban areas, or in areas such as agriculture, family planning, or nutrition (Gupta, 1995). Theory and research suggests that mass communication can act as a positive agent of social change for some people while impeding and obstructing change for others (Johnson, 2000). There are many who dispute the role played by the mass media in bringing about social change (Gupta, 1995; Rodrigues, 2010; Vilanilam, 2005). Gupta (1995) asserts that radio and television are the best sources for creating awareness and interest among the audience regarding a new message or idea â€Å"but when it comes to adoption of the idea, interpersonal sources such as extension agents, friends, neighbours, family members are the most effective† (Gupta, 1995, p.72). In the 1960s, communication scholars and media experts were quite sure that television and the other media of mass communication would help national development. The media were considered the prime motivators of development. Eminent communication scholars such as Daniel Lerner, Wilbur Schramm and Everett M. Rogers, who based their theories of development and media efficacy on the important work of Walter Rostow, namely, The Stages of Economic Growth, stressed that the economic and technological development achieved by the Western nations were the result of increased media use (Vilanilam, 2005). However, since the 1970s the dominant paradigms of development have been challenged by different disciplines (Gupta, 1995; Vilanilam, 2005). It has been realised that distribution of goods and services along with economic and political opportunities among the majority is a pre-requisite for development. An information revolution ushered into a largely private society without appropriate changes in the social structure will not benefit the large majority of the people (Vilanilam, 2005). Everett M. Rogers and many other theorists criticised the dominant paradigm of development (as cited in Rodrigues, 2010) and broadened its definition from one that centred on materialistic economic growth to other social values such as social advancement. The concept of development in the 1970s was expanded as a widely participatory process of social change in a society, intended to bring about both social and material advancement, including greater equality, freedom, and other valued qualities, for the majority of the people by giving them greater control over their environment. Similarly, the new concept of development communication that began to emerge dealt with the promotion of social change leading to improvement in people‟s quality of living, by encouraging better health, higher literacy and higher production of goods through more effective communication (Rodrigues, 2010). There was also a tendency in communication theory and practice to regard the television audience as passive beings moulded and manipulated by those who create the media messages (Johnson, 2000). Many development communication campaigns suffered on this count. However, it is increasingly being realised that for such messages to be effective, people must be involved at all stages – planning, production, and presentation. The need for localisation of development communication has been emphasised by many researchers and commentators (Joshi, 1985; Page and Crawley, 2001; Singhal and Rogers, 2001; Verghese, 1978). The Beginning of Television in India: In the name of Development When television was introduced in the country in 1959, it started as an experiment in social communication for which small teleclubs were organised in Delhi and provided with community television sets. Educational television began in 1961 to support middle and higher secondary school education. Its experiments in teaching of science, mathematics, and language proved successful and received appreciation from many UNESCO experts (Kumar, 2000). A few years later telecasts for farmers began in the form of Krishi Darshan. It was telecast on Wednesdays and Fridays for 20 minutes each day and served 80 villages (around Delhi) provided with community television sets. This pilot project was initiated by the Department of Atomic Energy in collaboration with the Ministry of Information and Broadcasting, All India Radio, the Indian Agricultural Research Institute and the Delhi Administration (Kumar, 2000). Vikram Sarabhai, the architect of India‟s satellite communication experiments, in 1969 presented a paper entitled â€Å"Television for Development† at the Society for International Development Conference in New Delhi. The idea that the backward countries can and should tap the most advanced communication technologies including television for leapfrogging into rapid economic growth and social transformation was first presented here (Joshi, 1985). Indian television in its infancy was managed by All India Radio. In 1976, television was separated from radio and given a new name – Doordarshan. This adjunct arrangement is seen by some commentators as an impediment to the natural development of television in its initial years (Page and Crawley, 2001). The public service broadcaster – Doordarshan has been used over the years to deliver a number of useful messages. These include messages on family planning, immunization, nutrition of the mother and the child, the need to stem bias against the girl child, among others. Experience suggests that some communication campaigns have worked better than others. A key reason for the failure of many development communication campaigns was the lack of co-ordination with field level agencies (Ninan, 1995; Singhal and Rogers, 2001). Ninan (1995) explains just why the family planning message, the mainstay of development communication messages on television, failed to work. She attributes the failure to the inability of state agencies to provide back-up facilities in rural areas that were required to make the campaign successful. On the other hand, certain messages conveyed through television have worked well. Notable in this category are the health, hygiene, sanitation, and oral rehydration messages which people have adopted to a large extent (Ninan, 1995). Educational Television is another area in which Doordarshan has made significant contribution. Ever since the inception of television in India in 1959, one major responsibility entrusted to it is to provide support for the education system in the country. School television (STV) was launched in October 1961 as an organised, systematic and sequential support to formal school instruction. Teachers appreciated STV as a tool for teaching and presentation of content (Kumar, 2000). The country-wide classroom initiative of the University Grants Commission dedicated to higher education started its telecast on Doordarshan in 1984 with one-hour educational programmes. Though the urban youth may not even be aware of such programmes, these were found to be very useful in the small towns and remote areas of the country where people had less access to other sources of information (Ninan, 1995). In order to boost educational telecasts, a satellite channel devoted exclusively to education Gyandarshan was launched in 2000 in collaboration with the Ministry of Human Resource Development and the Indira Gandhi National Open University. Gyandarshan offers interesting and informative programmes of relevance to special categories – pre-school kids, primary and secondary school children, college and university students, youth seeking career opportunities, housewives, adults, and many others. In addition to educational fare, programmes from abroad are also broadcast to offer viewers a window to the world (Agrawal and Raghaviah, 2006). For three decades ever since the inception of television, the dominant theme was communication for development so as to improve the quality of life for the vast rural majority. The logic was that in an underdeveloped, largely rural country; television could be used to convey messages on agricultural improvement, health care, and family planning to millions of people without depending on the extension infrastructure such a task would normally require. But the irony was that none of this was done imaginatively or consistently (Ninan, 1995). Commenting on the weaknesses of India‟s educational and instructional broadcasts, the Verghese Committee set up in 1977 to suggest an autonomous framework for broadcasting, noted that in the absence of co-ordination with concerned government departments and educational institutions; the health, farm and educational broadcasts have not been very effective. Another area where it felt the broadcast media was found inadequate was in promoting social justice and educating the underprivileged about their rights (Verghese, 1978). Despite some such shortcomings, Indian television also has to its credit significant initiatives of promoting social change in rural areas. Notable among them are SITE, the educational telecasts and the Kheda Communication Project. One of the most extensive educational and social research projects, perhaps the largest national television experiment in the world, has been SITE (Vilanilam, 2005). Some of these landmark initiatives are discussed in the next section. Landmark Initiatives in Development Communication using Television The journey of television in India took a new turn with the launch of the Satellite Instructional Television Experiment in 1975-76. It was a one year pilot-project using the National Aeronautics and Space Administration‟s ATS-6 satellite to broadcast educational messages through satellite to 2400 villages in the six states of Andhra Pradesh, Karnataka, Bihar, Orissa, Rajasthan and Madhya Pradesh. Its objectives were to improve rural primary education, provide teacher training, improve agriculture, health and hygiene, and nutritional practices and contribute to family planning and national integration (Singhal and Rogers, 2001). SITE was â€Å"an unqualified success in terms of hardware but the software wasn‟t specific enough to the area and audience in content or language, and therefore was not so useful and comprehensible† (Joshi, 1985, p.32). The important lesson learnt was that the software has to be area-specific, relevant to the needs and aspirations of the audience, and has to be in the local language (Page and Crawley, 2001; Singhal and Rogers, 2001). The Kheda Communication Project (KCP) launched in 1976 remains to-date the most innovative experiment in using television for empowerment and participatory rural development. Initially known as Pij TV, it used a one-kilowatt transmitter. The Pij transmitter could be received in a radius of about 30 km from Pij village (Agrawal and Raghaviah, 2006). It was India‟s first effort at decentralised community television broadcasting and received the prestigious UNESCO-IPDC prize for rural communication effectiveness. Some 650 community television sets were provided to 400 villages and installed in public places. One of the reasons for the success of the KCP was due to its ability to tap into the existing development infrastructure of Kheda district. It collaborated with extension agencies working in dairying, agriculture and health services, with local banks, cooperatives and employment exchanges (Singhal and Rogers, 2001). The accent was on participatory programme making, the themes were often local, dared to deal with controversial subjects such as caste discrimination, alcoholism etc., and for the first time systemic audience research was carried out (Thomas, 2010). Recognising it contribution, UNESCO noted, â€Å"Kheda was an exceptional example of the combining of modern technologies with a participatory approach to communication. The project employed traditional cultural expressions of a rural community in the creation of its audiovisual programmes, while using modern evaluation techniques for its programme planning. Overall, this project proved to be a good example of the applications of 9 communication for the promotion of human development, particularly of the rural poor, women and children† (UNESCO website, 2011, para. 14). Despite being such a success, the Kheda Project was carried out in splendid isolation from the mainstream and its lessons were not allowed to influence the development and programme trajectory adopted by Doordarshan (Thomas, 2010).

The Age Of Jackson A Period Of American History Essay

The Age of Jackson, from the 1820 s to the 1830 s, was a period of American history full of contradictions, especially in regard to democracy. The period saw an immense increase in voter participation, nominating committees replaced caucuses, and electors began to be popularly elected. Yet, all of these voting changes affected only a minority of the American people: White, Anglo-Saxon males. So, though one can easily tell that White, Anglo-Saxon males were gaining true liberty and equality, the millions of women. Blacks, Native Americans, immigrants, and other minorities in America continued to languish in a society that ignored their rights. Furthermore, during the Age of Jackson, enslavement of Blacks, the ultimate form of inequality, was at a new high in America. At the same time, enormous disparities of wealth existed between rich merchants, industrialists and planters, and their lowly workers: immigrants. Blacks, and the common man. While these contradictions typified America, J acksonian democrats viewed themselves as guardians of the Constitution, political democracy, individual liberty, and equality of opportunity. But how could anyone be a successful guardian of these ideals while contradictions such as those previously mentioned exist? The answer is that Jackson and his followers must have been what they said they were only to a certain extent. The Jacksonian Democrats were, to some extent, champions of the Constitution, democracy, liberty, and equality.Show MoreRelatedThe Age Of Jackson s Political History1074 Words   |  5 PagesThe Age of Jackson On particular, The Age of Jackson changed America’s political history because Jackson established new precedents with the government’s relations with Indians, the issue of state and federal rights and also established a political rivalry. The Age of Jackson occurred during the time period from 1829 to 1837. During this time period, the United Stated of America was under the presidential term of Andrew Jackson. Ever since Andrew Jackson’s election, there was a complete transformationRead MoreAnalysis Of Andrew Jackson s Life And Presidency Fall Under Constant Scrutiny Essay1369 Words   |  6 PagesWhen it comes to the study of American History, we tend to focus on the favorable, nationalistic inspiring narratives. In these narratives we analyses the many presidents, assassins, or military leaders in their gain of God, glory and gold. Some people, we study, for who they are their accomplishments and achievements. We look at how they helped progress America, and in some cases, we look at how they ruined America. One former president gets the popularity of either being America’s top leader orRead MoreJacksonian Dbq1652 Words   |  7 PagesThe Age of Jackson, from the 1820s to the 1830s, was a period of American history full of contradictions, especially in regard to democracy. 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Society and the individuals that shaped its very being were influenced greatly by not just the land around them, but the people who came forth and represented it. From 1787 to 1861, America experienced an increased fluctuate of these particular individuals. For example Alexander Hamilton, Frederick Douglas, and Andrew Jackson. Each of those named re igned in their own quarters leaving an influential

Analysis Of The Things They Carried By Tim O Brien

The Effects of What They Carried Loud explosions and small pings from distant rifle fire ring throughout the humid air. Short flashbacks are flooding back as sleep slowly seems so far away. Tim O’Brien, who was a Vietnam veteran, wrote several of stories about the war and the terrifying experiences that he was forced to have. One specific story is â€Å"The Things They Carried†. In this short story, he remembers what it was like to be a soldier; what his priorities were, the things he saw, and what still haunts him to this day. He also speaks about the items which he kept with him, both personal and regulation equipment, and even what his comrades lugged around. The most important thing that he talks about is how the war has affected his fellow soldiers both mentally and physically. This is known as PTSD or Post-Traumatic Stress Disorder which can be caused by more than just war. For instance, Roosevelt Roberts who worked at the Pentagon was one of the first responders of the plane crash during the Sep tember eleventh terrorist attack. He describes the events in great detail to interviewer, Jennifer Roberts. He mentions things that he cannot get out of his head, like the smell of burning flesh which is very common with PTSD. What can say with certainty is that these two men have something in common and it is PTSD. The Vietnam War did not end until 1975 and was the bloodiest war that the United States has ever been a part of. Due to this, thousands and thousands of the war veteransShow MoreRelatedAn Analysis Of Tim O Brien s Things They Carried1183 Words   |  5 Pagespoetic qualities such as literary devices, imagery, and theme, and many more. Tim O’Brien’s Things They Carried depicts a fragmented stories about his and other soldiers’ experiences that occurred in the Vietnam War. Similarly, the poem, â€Å"Facing It† shows a soldier who returns to the Memorial of the Vietnam War where he recalls his own trauma in the war as he looks at the stones. Both the prose, Things They Carried and the poem, â€Å"Facing it† conveys the similar theme where they are struggling toRead MoreAnalysis Of Tim O Brien s The Things They Carried Essay1574 Words   |  7 Pages To Ban or not to Ban : The Things They Carried Host: Hello and welcome to ban or not to ban, where the nations most exciting topics are discussed between opposing parties. Today we re debating whether or not to ban â€Å"Tim O Brien s novel The Things They Carried. In this book author Tim O’Brien depicts the Vietnam conflict by distinguishing between the role of whether or not to be a civilian or a soldier. 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In order to express the tension in the war, O’Brien depicts the experience ofRead MoreAnalysis Of Tim O Brien s The Things They Carried1097 Words   |  5 Pages The Silent Killer: An Analysis of Imagination Evolving into a Distraction in Tim O’Brien’s â€Å"The Things They Carried† In Tim O’Brien’s â€Å"The Things They Carried†, O’Brien created several allusions that each character endured during the Vietnam War. Throughout the story were vast representations of the things the soldiers carried both mentally and physically. The things they carried symbolized their individual roles internally and externally. In addition to the symbolism, imaginationRead MoreAnalysis Of Tim O Brien s The Things They Carried 1187 Words   |  5 PagesThere were many things the soldiers carried with them during the Vietnam War. They carried guns and ammo, rations and canteens, and things necessary for survival. The soldiers also carried letters, photographs and land of Vietnam itself. Tim O’Brien tells of this in The Things They Carried, a book detailing the lives of the soldiers in Vietnam through the things the men carried with them. Not everything the men carried was physical, however. The soldiers carried ghosts, memories, and burdens. Ever yoneRead MoreAnalysis Of Tim O Brien s The Things They Carried Essay2347 Words   |  10 PagesThe decision to go to war is not a decision that is taken lightly. In Tim O’Brien’s The Things They Carried, Tim O’Brien faces cultural, social and political push factors that end up leading him to forgo his plan to dodge the draft, and to report as instructed, a mere yards away from his destination of Canada. In Leslie Marmon Silko’s Ceremony, Rocky and Tayo, two young Native American men, experience cultural, social and political pull factors that draw them into the Army, fighting the Second WorldRead MoreAnalysis Of Tim O Brien s The Things They Carried All Experience1859 Words   |  8 PagesYou: Tim O Brien s Methods To Overcome Loss Throughout the 1980s, Dr. Terence M. Keane ran experiments on a new idea called exposure therapy. The case studied how victims of trauma would react to being repeatedly shown places, imagines, and stories that mirrored theirs. In the study was twenty four veterans of the Vietnam War, and at the end of the study, they no longer had reactions classified as severe anxiety. Like the veterans in this case study, soldiers in Tim O Brien s The Things TheyRead MoreAnalysis Of Tim O Brien s The Things They Carried During The War Essay1532 Words   |  7 PagesIn this paper I will argue that in Tim O’Brien’s The Things They Carried during the war a person experience develop guilt from an event that happened during the war and how it affects them for life. The three people specifically, I will take about are First Lieutenant Jimmy Cross, Norman Bowker, and Tim. Telling about how the experienced guilt, where the guilt comes from, and if they ever find absolution. The first story of two stories for First Lieutenant Jimmy Cross feels guilty about the deathRead More Things They Carried Essay: Disembodiment723 Words   |  3 PagesDisembodiment in The Things They Carried  Ã‚  Ã‚   With some knowledge of war, one can begin to appreciate Tim O Briens The Things They Carried.   But when the work is viewed in its strict historical context, another layer of   meaning rises to the surface.   Tim O Brien is a veteran; as a result there are many things he takes for granted (or so we think) and does not tell us.   Americas involvement in the Vietnam war resulted from internal domestic politics rather than from the national spirit.  Read MoreEssay On The Things They Carried1624 Words   |  7 PagesFor the seventeen Soldiers portrayed in â€Å"The Things We Carried† by Tim O’Brien, the physical pain was very minimal weight to carry compared to the emotional scars that they will carry throughout their entire life. This story does an amazing job portraying full human emotion that anyone put into a situation would feel, such as heavy guilt, sadness, anger, lack of motivation, perseverance, horror, and false security. All of these are notorious feel ings that every soldier back in history, and now still